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ABG: Directory of 3D structures of antibodies
- The directory, created by the Antibody Group (ABG), allows a quick
access to the antibody structures compiled at the Protein Data Bank
(PDB). In the directory, each PDB entry has a hyperlink to the original
source to make full information recovering easy. The VH and VL
sequences were aligned and are reported in the VH and VL alignments.
The directory will be updated monthly.
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ABG: Germline gene directories of the mouse - a directory of mouse VH and VK germline segments, part of the webpage of the Antibody Group at the Instituto de Biotecnologia, UNAM (National University of Mexico)
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AbMiner
- users can search for commercially available antibodies and match them
with their respective genomic identifiers. A unique feature of this
database is that only antibodies screened by Western blot are included,
which makes the antibodies listed research friendly.
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Abnum
- an online tool that lets you number an antibody sequence or structure
automatically using the Kabat or Chothia schemes, as well as a new
improved Clothia scheme created by the authors.
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Antibody Central
- an antibody search portal which connects catalog antibodies and
research publications to the UniProt protein information resource. The
tool uses a proprietary Antibody Name Dictionary model - a collection
of protein names, synonyms, and symbols recognized as antibody names
which are verified through a full-text search of scientific
publications in HighWire Press.
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European Collection of Animal Cell Cultures
- available cell lines include those stored by the ATCC and the ECACC (the European Human Cell Bank and the Hybridoma Collection)
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HIV Molecular Immunology Database
- listings of HIV specific monoclonal antibodies, maps of binding sites
on HIV proteins, sequence alignments showing global variation of linear
binding domains, brief descriptions of how the MAb has been used in HIV
studies with Medline links, and where to obtain many of the antibodies
in the database.
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The Hybridoma Databank
- HDB holds data on various aspects of hybridomas and their
immunoreactive products. Information on a hybridoma's construction and
the reactivity and non-reactivity of its secreted product is included.
In addition, information on the availability of an individual hybridoma
and its Mab product are included. Information in the HDB is derived
from literature, catalogs and survey forms.
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IMGT Æ, the international ImMunoGeneTics information system Æ
- created in 1989 by Marie-Paule Lefranc (UniversitÈ Montpellier II,
CNRS), IMGT is an integrated knowledge resource specializing in
immunoglobulins, T cell receptors, major histocompatibility complex,
immunoglobulin superfamily , major histocompatibility complex
superfamily, and related proteins of the immune system for human and
other vertebrate species. IMGT consists of sequence databases
(IMGT/LIGM-DB, a comprehensive database of IG and TR from human and
other vertebrates, with translation for fully annotated sequences,
IMGT/MHC-DB, IMGT/PRIMER-DB), a genome database (IMGT/GENE-DB), a
structure database (IMGT/3Dstructure-DB), a web resource (IMGT
Repertoire), and interactive tools (IMGT/V-QUEST,
IMGT/JunctionAnalysis, etc...). The IMGT home page provides a common
access to all Immunogenetics data.
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The Kabat database - search the Kabat database of sequences of proteins of immunological interest. This site is updated frequently.
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Kabatman
- A great source of information for molecular biologists and
crystallographers on the structure of antibodies. This site also
contains the KabatMan database which allows you to search the Kabat
sequence database to look for sequence features, AbCheck which lets you
test your antibody sequence against the Kabat sequence database to look
for unusual features, and Chothia which lets you find canonical
assignments for the CDRs in your antibody sequence.
- Monoclonal Antibody Index
- a biotechnology database with yearly updated information on more than
9000 monoclonal antibodies produced for the diagnosis an-d therapy of
cancer, transplant, infection, heart-related disorders, etc...
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PIGS - Prediction of ImmunoGlobulin Structures
- use this web interface to automatically model immunoglobulin variable
domains based on the canonical structure method. The output is a 3D
model of the target antibody that can then be downloaded or displayed
online.
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RosettaAntibody
- a FV homology modeling server - a homology modeling server that
predicts antibody Fv region structures using knowledge-based techniques
for template selection, de novo loop modeling for creating
CDR-H3, grafting for non-H3 CDR loops, and docking to optimize the
orientation of the light and heavy chains.
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SACS - (Summary of Antibody Crystal Structures) is an automatically updated summary of all antibody structures in the Protein Data Bank
(PDB). New PDB files processed immediately as they arrive to determine
whether they are antibodies and if so, relevant information is
extracted and made available on the web.
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SCOP
- search "SCOP" (structural classification of proteins) for references
and structural information on antibodies by keyword or sequence
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STATdxPathIQ
- formerly Immunoquery. STATdxPathIQ is a diagnostic decision making
tool for pathology that uses current, peer-reviewed literature to
suggest immunohistochemical panels for the differentiation of similarly
appearing tumor types. The website also contains high quality typical
and atypical histochemical and immunohistochemical images to aid
researchers in differential diagnosis. STATdxPathIQ evolved from
ImmunoQuery, a meta-analysis search engine for use by pathologists.
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V BASE
- V BASE is a comprehensive directory of all human germline variable
region sequences compiled from over a thousand published sequences,
including those in the current releases of the Genbank and EMBL data
libraries.
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WAM - Web Antibody Modelling
- WAM is an online facility for generating a 3D model of an antibody Fv
from its sequence. Based on Oxford Molecular's AbM, WAM uses sequence
homology to build the frameworks, the most sequence-homologous member
of the canonical class to construct the canonical loops, and a
combination of database and conformational searches to construct the
non-canonical loops. The putative models are then screened using a
combination of energetic and knowledge-based approaches. Modelling is
free for the first model for academic users; there is a small charge
($100) for subsequent models. See the web site for more details for
commercial users.
- Go here if you are looking for general peptide sequencing (proteomic) software.